Radical Celeb Weight-Loss Transformations, Ever

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It's no secret that Hollywood pressures its stars to slim down and tone up. But even celebrities gain big from time to time: They're human too, after all! It's time to take a look at the biggest weight-loss transformations in the biz. How did they pull it off, and what are the best-kept secrets?

Kirstie Alley

Kirstie Alley stole America's heart in the Look Who's Talking comedies. And who can forget her role on Cheers? With a place firmly in Hollywood history, her place in the industry was secure. Or was it? When she began to put on weight, her opportunities scattered for years to come!

To fight back, Kirstie joined Jenny Craig: In three years, she lost 75 pounds and became the spokeswoman. Evidently, some meal programs do work out!

Extreme evolution, next: The famous faces that shed the most, pound for pound!